Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. Not like opioids, which bind to µ-opioid receptors while in the central nervous system, conolidine modulates alternate molecular targets. A Science Improvements examine uncovered that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://whatisthedrugconolidineus93467.blogtov.com/19450398/a-review-of-alternative-natural-pain-relief-to-replace-traditional-painkillers