The central nervous system (CNS) is a very challenging HIV-1 sanctuary. in which HIV-1 replication is established early on during acute infection and can persist despite potent antiretroviral treatments. HIV-1 infected macrophages play a pivotal role acting as vehicles for HIV-1 to spread into the brain. and can be the major contributor of an early compartmentalization. https://macorners.shop/product-category/leather-patch-hat/