There is a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to lower afferent ache transmission and produce analgesia. As a result, medicines like clonidine that target alpha-two receptors can impact the transmission of pain. Clonidine is a protracted-expression medication. https://rogerg396nnm0.bmswiki.com/user