In this article, we demonstrate that conolidine, a pure analgesic alkaloid used in standard Chinese drugs, targets ACKR3, thus giving additional evidence of the correlation involving ACKR3 and ache modulation and opening different therapeutic avenues with the treatment of Long-term pain. In such cases, it improves the Conolidine’s bioavailability, https://proleviatenaturespainkill77542.p2blogs.com/30741443/about-what-is-conolidine