Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts from the microenvironment and growing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactions, which ... https://enricog196xfl2.ourabilitywiki.com/user