In this article we demonstrate that DNL343 minimizes ISR activation and neurodegeneration introduced on acutely by an optic nerve crush (ONC) injuries or chronically by a germline eIF2B LOF mutation in mice. We also show that DNL343 therapy, initiated in a late phase of disorder which additional precisely replicates a https://kn-9343210.bloguerosa.com/27740297/pco371-an-overview